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BACKGROUNDUS breast cancer mortality is declining, but thousands of women still die each year.
METHODSTwo established simulation models examine 6 strategies that include increased screening and/or treatment or elimination of obesity versus continuation of current patterns. The models use common national data on incidence and obesity prevalence, competing causes of death, mammography characteristics,...
BACKGROUNDAndrogen receptor (AR) expression in breast cancers may serve as a prognostic and predictive marker. We examined the expression pattern of AR and its phosphorylated forms, Ser‐213 (AR‐Ser[P]‐213) and Ser‐650 (AR‐Ser[P]‐650), in breast cancer and evaluated their association with clinicopathological parameters.
METHODSImmunohistochemistry was performed on primary and distant metastatic breast...
BACKGROUNDThere is no standard treatment for progressive epithelioid hemangioendothelioma (EHE). To investigate the significant vascularization of EHE, the activity/toxicity of sorafenib in patients with progressive EHE was explored.
METHODSIn this multicenter, 1‐stage, phase 2 trial of sorafenib (800 mg daily), the primary endpoint, which was chosen by default, was the 9‐month progression‐free rate...
BACKGROUNDThe objective of this study was to evaluate local control and patterns of failure in pediatric patients with low‐grade glioma (LGG) who received treatment with intensity‐modulated radiation therapy (IMRT).
METHODSIn total, 39 children received IMRT after incomplete resection or disease progression. Three methods of target delineation were used. The first was to delineate the gross tumor...
BACKGROUNDOptimal management of children with centrally located low‐grade glioma (LGG) is unclear. Initial interventions in most children are chemotherapy in younger and radiation therapy (RT) in older children. A better understanding of the inherent risk factors along with the effects of interventions on long‐term outcome can lead to reassessment of the current approaches to minimize long‐term morbidity...
BACKGROUNDIn this multicenter, open‐label, randomized phase 2 trial, the authors evaluated the vascular endothelial growth factor receptor inhibitor axitinib, bevacizumab, or both in combination with chemotherapy as first‐line treatment of metastatic colorectal cancer (mCRC).
METHODSPatients with previously untreated mCRC were randomized 1:1:1 to receive continuous axitinib 5 mg twice daily, bevacizumab...
BACKGROUNDChemotherapy has improved the outcome of patients with newly diagnosed osteosarcoma, but its role in relapsed disease is unclear.
METHODSWe reviewed the records of all patients who were treated for relapsed high‐grade osteosarcoma at our institution between 1970 and 2004. Postrelapse event‐free survival (PREFS) and postrelapse survival (PRS) were estimated, and outcome comparisons were...
BACKGROUNDIn this phase 2 study, the authors evaluated the efficacy, safety, and tolerability of the Aurora B kinase inhibitor barasertib compared with low‐dose cytosine arabinoside (LDAC) in patients aged ≥60 years with acute myeloid leukemia (AML).
METHODSPatients were randomized 2:1 to receive either open‐label barasertib 1200 mg (as a 7‐day intravenous infusion) or LDAC 20 mg (subcutaneously...
BACKGROUNDIn November 2009, the US Preventive Services Task Force (USPSTF) issued new recommendations regarding mammography screening. The Task Force recommended against routine screening for women ages 40 to 49 years and recommended biennial screening for women ages 50 to74 years. The recommendations met great controversy in mass media and medical literature; whether they have had an impact on screening...
BACKGROUNDChemotherapy‐induced neutropenia has been associated with prolonged survival selectively in patients on a conventional schedule (combined 5‐fluorouracil, leucovorin, and oxaliplatin [FOLFOX2]) but not on a chronomodulated schedule of the same drugs administered at specific circadian times (chronoFLO4). The authors hypothesized that the early occurrence of chemotherapy‐induced symptoms correlated...
BACKGROUNDUterine serous carcinoma (USC) is a subtype of endometrial cancer associated with chemoresistance and poor outcome. Overexpression of tubulin‐β‐III and p‐glycoprotein has been linked to paclitaxel resistance in many cancers but has been undercharacterized among USCs. Epothilones have demonstrated activity in certain paclitaxel‐resistant malignancies. In this study, relationships are clarified,...
BACKGROUNDA recent review of the Surveillance, Epidemiology, and End Results registry suggested that patients with index squamous cell carcinoma (SCC) of the oropharynx (SCCOP) are less likely to develop second primary malignancies (SPM) than patients with index SCC of nonoropharyngeal sites (oral cavity, larynx, hypopharynx). The objectives of this study were to determine the impact of index primary...
BACKGROUNDOutcomes for patients with chronic myeloid leukemia (CML) have improved after the advent of tyrosine kinase inhibitors (TKIs), which target the BCR/ABL fusion gene product. Nonetheless, differences in survival persist between age groups. The authors performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database to assess 5‐year overall survival...
BACKGROUNDA patient navigation process is required for accreditation by the National Accreditation Program for Breast Centers (NAPBC). Patient navigation has previously been shown to improve timely diagnosis in patients with breast cancer. This study sought to assess the effect of nurse navigation on timeliness of care following the diagnosis of breast cancer by comparing patients who were treated...
BACKGROUNDThe objective of this study was to determine whether age, sex, a positive family history of colorectal cancer, and body mass index (BMI) are important predictors of advanced neoplasia in the setting of screening computed tomographic colonography (CTC).
METHODSConsecutive patients who were referred for first‐time screening CTC from 2004 to 2011 at a single medical center were enrolled. Results...
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